Research of different loading doses of sufentanil using for analgesia on patients after gastrointestinal operation

Objective To observe the effects of sufentanil with different loading doses in patients controlled intravenous analgesia(PCIA)after gastrointestinal operation,to determine the best loading doses of sufentanil. Methods Sixty patients after gastrointestinal operation were randomly divided into three groups,20 cases in each group.Group A received 5 μg sufentanil,group B received 10 μg sufentanil and group C received 20 μg sufentanil.The loading doses were given 30 min before the end of operation.PCIA(included sufentanil 2 μg/kg) with a bolus dose of 2 mL,lockout interval of 15 minutes and continuous infusion of 2 mL/h was given after extubation.Visual analogue scales(VAS),sedation score,PCA palpation times,adverse effects and degree of satisfaction were observed at 1,4,12,24 and 48 h postoperatively. Results VAS score was lower in group B and group C than that in group A on the first 4 h(P0.05),no significant difference was observed between group B and group C.Sedation score in first 4 h and the incidence of adverse effects(such as abdominal distention,nausea and vomiting) were lower in group A and group B than those in group C(P0.05).PCA palpation times were less in group B and group C than those in group A.Degree of satisfaction was higher in group B and group C than that in group A. Conclusion PCIA with 10 μg sufentanil loading dose can provide a good postoperative analgesia effect safely for gastrointestinal surgical patients.