Therapeutic Effect of Guyangding Prescription on Knee Osteoarthritis with Liver-kidney Insufficiency and Qi Deficiency and Blood Stasis

Objective To observe the therapeutic effect of Guyangding Prescription(GP) on knee osteoarthritis(OA) with liver-kidney insufficiency and Qi deficiency and blood stasis.Methods One hundred and six qualified patients were randomized into two groups:54 in the treatment group received GP(mainly composed of Radix Astragali,Flos Carthami,Rhizoma Drynariae,Fructus Psoraleae,Fructus Chaenomelis,Radix Achyranthis Bidentatae,etc.),and 52 in the control group received celecoxib.Four weeks constituted one treatment course,and the therapeutic effect and the safety were evaluated after 12 weeks.Results After treatment,the total effective rate was 94.44% in the treatment group,and 82.70% in the control group,and the difference was significant(P 0.05),indicating that the therapeutic effect of GP was superior to that of celecoxib.During the treatment,no adverse effect was found.Conclusion GP is effective on relieving pain in the knee joint and improving knee function of knee OA patients with liver-kidney insufficiency and Qi deficiency and blood stasis.Its effect is better than celecoxib,without toxic or side effects.