2006•Journal of Practical Diagnosis and TherapyRequires access
Change of serum postate specific antigen and free prostate spectific antigen contents in advanced prostate cancer patients treated with bicalutamide
Zhou Huash
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Abstract
Objective To investigate the clinical significance of changes in prostate specific antigen,and changes in proportions of free prostate apecific antigen with total prostate specific antigen(FPSA/PSA) in patients with advanced prostate cancer after treated with bicalutamide.Methods Serum prostate specific antigen and free prostate specific antigen contents were determined before treatment and 1,3,6 months after treatment.Results Serum of prostate specific antigen was greatly decreased 1 month after therapy.The serum prostate spectific antigen was significantly decreased in 6 months compared with that in 1 month after treatment.Serum free prostate specific antigen was obviously decreased in all patients after therapy.Conclusion Serum prostate specific antigen and free prostate specific antigen evaluation is useful in prostate cancer patients undergoing hormonal therapy.Bicalutamide therapy is effective for advanced prostate cancer patients.