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2010•Journal of Southeast UniversityRequires access

Research progress in matrix metalloproteinases and their inhibitors of heatocellular carcinoma

Lu Fenglin

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Abstract

The matrix metalloproteinase(MMP) family is an important enzyme degrading extracellular matrix,and the tissue inhibitor of metalloproteinase(TIMP) is a natural inhibitor of MMP.The imbalance of MMPs and TIMPs in the extracellular matrix has confirmed to relate with a variety of pathological states,especially tumor invasions and metastasis.Here,a review concerning about the research proceeding of the structures and functions of MMPs and TIMPs,the relationship between them and hepatocellular carcinoma(HCC) invasion or metastasis is presented.

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What this paper is about

The matrix metalloproteinase(MMP) family is an important enzyme degrading extracellular matrix,and the tissue inhibitor of metalloproteinase(TIMP) is a natural inhibitor of MMP.The imbalance of MMPs and TIMPs in the extracellular matrix has confirmed to relate with a variety of pathological states,especially tumor invasions and metastasis.Here,a review concerning about the research proceeding of the structures and functions of MMPs and TIMPs,the relationship between them and hepatocellular carcinoma(HCC) invasion or metastasis is presented.

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Available abstract

The matrix metalloproteinase(MMP) family is an important enzyme degrading extracellular matrix,and the tissue inhibitor of metalloproteinase(TIMP) is a natural inhibitor of MMP.The imbalance of MMPs and TIMPs in the extracellular matrix has confirmed to relate with a variety of pathological states,especially tumor invasions and metastasis.Here,a review concerning about the research proceeding of the structures and functions of MMPs and TIMPs,the relationship between them and hepatocellular carcinoma(HCC) invasion or metastasis is presented.

Key concepts: Matrix metalloproteinase, Extracellular matrix, Metastasis, Hepatocellular carcinoma, Matrix metalloproteinase inhibitor, Cancer research, Tissue inhibitor of metalloproteinase, Matrix (chemical analysis)

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