The suppressive effects of low-dose Ketamine on the patients with postoperative hyperalgesia after remifentanil-based Anaesthesia

Objective To study the suppressive effects of low-dose ketamine on postoperative hyperalgesia after remifentanil-based anaesthesia.Methods A total number of ninety ASA I～Ⅱ famale adult patients who undergone the operation of hysteroscope and peritoneoscope on were assigned to three groups randomly.Controll-ed group(Group C)、remifentanil group((Group R) and low-dose ketamine group(Group K).Before the end of surgery Group K was given ketamine 0.5 mg/kg and Group C and R wasn’t given any medicine.When the patients feel the moderate ache tramadol 2mg/kg was given.VRS score,the time of requiring analgesia by patients and adverse drug reactions such as nausea,vomit,diplopia and hallucination were recorded for 24 hours after surgery.Results After operation the VRS score of Group C was lower than group R(P0.05) and Group K was lower than other groups(P0.05).All groups hadn’t requiring analgesia any more.The adverse drug reaction showed no significant difference in three groups.Conclusion Low-dose ketamine has significant suppressive effect on patients with postoperative hyperalgesia after remifentanil-based anaesthesia.