Efficacy and safety of high-dose cisplatin with glulathione protection in the treatment of malignant tumors (A Report of 85 Cases)

Objective: To observe and evaluate the efficacy of glulathione in the treament of renal toxicity caused by cisplatin based chemotherapy.Methods: All the advanced malignancy cases were proved by pathology including None small cell lung cancer(27 cases),digestive cancer (39cases)and ovary carcinoma (19cases).The patients received combination chemotherapy based on high dose cisplatin.The dose of cisplatin was 70～80mg,d1～d3.(total 150mg～240mg).At the same time,glutathione was offered from d1-d3.The dose was 1.5g/m2 ,d1～d5 .Results : The response rate of combination chemotherapy with high dose cisplatin was over 50%,and the values of great,Bun,u-protein and electrolytes were normal .Conclusion: Glutathione has good protection on renal function.It can reduce the application of chemotherapy based on high dose cisplatin.