ScholarLens Back to search
2012•Traditional Chinese Drug Research and Clinical PharmacologyRequires access

Effects of Timosaponin on Absorption of Mangiferin

Peng Pei

Open publisher page 2 citations

Abstract

Objective To investigate the effects of timosaponin on absorption of mangiferin by in-vivo and in-vitro methods.Methods LC/MS/MS method was used to determine plasma mangiferin concentration in rats after intragastric administration of mangiferin or mangiferin mixed with timosaponin,and the main pharmacokinetic parameters were calculated.Intestinal absorption of mangiferin was studied by using everted gut sacs and by UPLC.Results Compared with mangiferin group,the plasma concentration,AUC and Cmax of mangiferin were significantly increased,and Tmax was prolonged to 3 h in mangiferin-timosaponin group.Q90,Vt and Paap of mangiferin at ileac segment of rats in timosaponin-mangiferin(1∶1) group were higher than that in mangiferin monomer group(P 0.05).Conclusion Timosaponin can increase the absorption of mangiferin.

About this research paper

What this paper is about

Objective To investigate the effects of timosaponin on absorption of mangiferin by in-vivo and in-vitro methods.Methods LC/MS/MS method was used to determine plasma mangiferin concentration in rats after intragastric administration of mangiferin or mangiferin mixed with timosaponin,and the main pharmacokinetic parameters were calculated.Intestinal absorption of mangiferin was studied by using everted gut sacs and by UPLC.Results Compared with mangiferin group,the plasma concentration,AUC and Cmax of mangiferin were significantly increased,and Tmax was prolonged to 3 h in mangiferin-timosaponin group.Q90,Vt and Paap of mangiferin at ileac segment of rats in timosaponin-mangiferin(1∶1) group were higher than that in mangiferin monomer group(P 0.05).Conclusion Timosaponin can increase the absorption of mangiferin.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the effects of timosaponin on absorption of mangiferin by in-vivo and in-vitro methods.Methods LC/MS/MS method was used to determine plasma mangiferin concentration in rats after intragastric administration of mangiferin or mangiferin mixed with timosaponin,and the main pharmacokinetic parameters were calculated.Intestinal absorption of mangiferin was studied by using everted gut sacs and by UPLC.Results Compared with mangiferin group,the plasma concentration,AUC and Cmax of mangiferin were significantly increased,and Tmax was prolonged to 3 h in mangiferin-timosaponin group.Q90,Vt and Paap of mangiferin at ileac segment of rats in timosaponin-mangiferin(1∶1) group were higher than that in mangiferin monomer group(P 0.05).Conclusion Timosaponin can increase the absorption of mangiferin.

Key concepts: Mangiferin, Chemistry, Cmax, Chromatography, Pharmacokinetics, Absorption (acoustics), In vivo, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of Timosaponin on Absorption of Mangiferin — Research Paper | ScholarLens