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2011•Unpublished venueRequires access

In vitro release of ibuprofen from hydroxypropylmethylcellulose matrix tablets

HE Zhong-gui

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Abstract

Objectives To investigate the in vitro release and drug release mechanism of ibuprofen from HPMC matrix tablets. Methods Using ibuprofen as a model drug, HPMC matrix tablets were prepared using wet granulation method and the effect of HPMC viscosity, HPMC content and properties of filler on the in vitro release of ibuprofen from the matrix tablets were studied. Drug release mechanism was discussed. Results The release rate of ibuprofen from HPMC matrix tablets was mainly controlled by theviscosity of HPMC, content of HPMC and properties of the fillers. Drug release mechanism was Fickian diffusion and Erosion. Conclusions Ibuprofen sustained release tablets with ideal release behavior could be prepared by selecting HPMC with different viscosity and adjusting the content of HPMC.

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What this paper is about

Objectives To investigate the in vitro release and drug release mechanism of ibuprofen from HPMC matrix tablets. Methods Using ibuprofen as a model drug, HPMC matrix tablets were prepared using wet granulation method and the effect of HPMC viscosity, HPMC content and properties of filler on the in vitro release of ibuprofen from the matrix tablets were studied. Drug release mechanism was discussed. Results The release rate of ibuprofen from HPMC matrix tablets was mainly controlled by theviscosity of HPMC, content of HPMC and properties of the fillers. Drug release mechanism was Fickian diffusion and Erosion. Conclusions Ibuprofen sustained release tablets with ideal release behavior could be prepared by selecting HPMC with different viscosity and adjusting the content of HPMC.

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Available abstract

Objectives To investigate the in vitro release and drug release mechanism of ibuprofen from HPMC matrix tablets. Methods Using ibuprofen as a model drug, HPMC matrix tablets were prepared using wet granulation method and the effect of HPMC viscosity, HPMC content and properties of filler on the in vitro release of ibuprofen from the matrix tablets were studied. Drug release mechanism was discussed. Results The release rate of ibuprofen from HPMC matrix tablets was mainly controlled by theviscosity of HPMC, content of HPMC and properties of the fillers. Drug release mechanism was Fickian diffusion and Erosion. Conclusions Ibuprofen sustained release tablets with ideal release behavior could be prepared by selecting HPMC with different viscosity and adjusting the content of HPMC.

Key concepts: Ibuprofen, Granulation, Matrix (chemical analysis), Chemistry, Chromatography, Viscosity, Polyvinyl alcohol, Diffusion

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