Observation of the ultrastructure of nerve tissues in rabbit sciatic nerve injured by electrical current

Objective To observe the changes in the ultrastructure of nerve tissues and Schwann cells in rabbit sciatic nerve after electrical injury. Methods The experimental animals were randomly divided into 3 groups based on the use of voltage: 55 V, 110 V, and 220 V group. The rabbit model of injured sciatic nerve was established by shocking with different voltages. The ultrastructure of nerve tissues were observed under the transmission electron microcopy. Results (1)The ultrastructure of the injured sciatic nerve returned to normal 4 weeks after being shocked with 55 V. (2)Under the Voltage with 110 V, the injury of the nerve was aggravated on week 2 and the Schwann cells proliferated; the ultrastructure of the nerve almost returned to normal on week 16. (3)Shocked with 220 V, the Schwann cells were destroyed and the ultrastructure of the nerve remained abnormal on week 16. Conclusions Marked changes in the ultrastructure of nerve tissues occur with the increasing voltage in electrical injury. After electrical injury, the peripheral nerve regeneration is correlated to Schwann cell proliferation. Recovery of Schwann cells may be necessary in the successful regeneration of the nerve.