Content and Significance of Motilin (MTL) in Plasma and Gallbladder of Patients with Cholelithiasis

Objective The content of MTL in plasma and gallbladder wall tissue of the patients with cholelithiasis was measured to evaluate their role and clinical significance in the formation of gallstones with radioimmunoassay.Methods All patients were collected from the 2nd Affiliated Hospital of China University from Apr 2005 to Oct 2007.There were 36 patients of gallstones.Gallbladder polyps group:14patients were enrolled.Control group:Blood samples were collected from healthy doctors and nurses and relatives of patients.10 samples were collected.normal gallbladder wall tissue samples were collected from thr donor during liver transplantion,which were 7 samples.Results The plasma MTL lever in gallstone group was higher,compared with that of control and gallbladder polyp groups(P0.05).There was no statistical significance between gallbladder polyp group and control group.The same result was found beteen common bile stone group and control group and gallbladder poleop group.Results of gallbladder wall tissue MTL:the gallbladder wall tisse MTL lever in gallstone group was higher,compared with that of control and gallbaladder polyp groups(P0.05).There was not statistical significance between gallbladder polyp group and control group.Conclusion MTL level in the plasma and gallbaldder tissue increasd obviously.This may play a role in the pathogenesis of gallstones.