Gemfibrozil vs fenofibrate in treating hyperlipidemia

In 210 patients with hyperlipemia,109 patients(M60,F49;age 58±s 8 a) were treated with gemfibrozil 600 mg,po,bid×12 wk,and 101 patients(M66,F35;age 59±8a) were treated with fenofibrate 100 mg,po,bid×12 wk.Results shwed that in gemfibrozil group the levels of triglyceride(TG) and total cholesterol(TC) decreased 53.0%and 19.4% respectively, and high density lipoprotein cholesterol(HDL-ch) increased 26.8%(all P0.01).In fenofibrate group,the levels of TG and TC decreased 41.0% and 22.0%respectively and HDL-ch increased 22.0% (all P0.01).But the difference between the two groups was non significant (P0.05).No serious side effects were found during the therapeutic period,but 4 patients in gemfibrozil group and 5 patients in fenofibrate group had transient increase of GPT activity.