2007•The Chinese Journal of Clinical PharmacologyRequires access

Progress in relationship of cytochrome P450 1A2 genetic polymorphism,substance metabolism and carcinogenesis

Guoliang Zhang

Abstract

Cytochrome P450 1A2, a drug-metabolic enzyme with highly interindividual variability, is one of the most interested isoenzymes in the field of pharmacogenetics. It is involved in the metabolism of many prescribed drugs and environmental carcinogens, also related to the susceptibility of some diseases. Recently CYP 1A2 was reported as an anti-oxidant. Study in CYP 1A2 gene polymorphism and variety of CYP 1A2 activity might contribute to the evaluation of clinical therapy of drugs. Application of probe drug is the main method to evaluate CYP 1A2 activity. Moreover, the model of the humanized CYP 1A2 transgenic animals is a new method to investigate carcinogenesis.

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Key concepts: Cytochrome P450, Pharmacogenetics, Drug metabolism, Isozyme, Carcinogenesis, Carcinogen, CYP2D6, Biology