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2005•Journal of Practical Diagnosis and TherapyRequires access

Clinical study on the effect of paclitaxel combined with radiotherapy in the treatment of 28 patients with advanced non-small cell lung cancer

Qianbing Wan

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Abstract

Objective To evaluate the efficacy and toxicity of paclitaxel combined with radiotherapy in the treatment of advanced non-small cell lung cancer. Methods Twenty-eight patients with stage Ⅲ～Ⅳ non-small cell lung cancer which couldn’t be treated surgically received paclitaxel chemotherapy plus radiotherapy with medical linear accelerator. Results CR was achieved in 3 cases, PR in 17, NC in 6, PD in 2, the overall response rate(CR+PR) being 71.4%.CA125 was significantly lower than that before radiochemotherapeutic treatment(P0.05), and the side-effects were not serious. Conclusion Paclitaxel chemotherapy combined with radiotherapy with medical linear accelerator is a good method in the treatment of advanced non-small cell lung cancer which couldn’t be treated surgically.

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What this paper is about

Objective To evaluate the efficacy and toxicity of paclitaxel combined with radiotherapy in the treatment of advanced non-small cell lung cancer. Methods Twenty-eight patients with stage Ⅲ～Ⅳ non-small cell lung cancer which couldn’t be treated surgically received paclitaxel chemotherapy plus radiotherapy with medical linear accelerator. Results CR was achieved in 3 cases, PR in 17, NC in 6, PD in 2, the overall response rate(CR+PR) being 71.4%.CA125 was significantly lower than that before radiochemotherapeutic treatment(P0.05), and the side-effects were not serious. Conclusion Paclitaxel chemotherapy combined with radiotherapy with medical linear accelerator is a good method in the treatment of advanced non-small cell lung cancer which couldn’t be treated surgically.

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Available abstract

Objective To evaluate the efficacy and toxicity of paclitaxel combined with radiotherapy in the treatment of advanced non-small cell lung cancer. Methods Twenty-eight patients with stage Ⅲ～Ⅳ non-small cell lung cancer which couldn’t be treated surgically received paclitaxel chemotherapy plus radiotherapy with medical linear accelerator. Results CR was achieved in 3 cases, PR in 17, NC in 6, PD in 2, the overall response rate(CR+PR) being 71.4%.CA125 was significantly lower than that before radiochemotherapeutic treatment(P0.05), and the side-effects were not serious. Conclusion Paclitaxel chemotherapy combined with radiotherapy with medical linear accelerator is a good method in the treatment of advanced non-small cell lung cancer which couldn’t be treated surgically.

Key concepts: Medicine, Paclitaxel, Radiation therapy, Lung cancer, Chemotherapy, Oncology, Lung, Internal medicine

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