2000•Unpublished venueRequires access

REGULATION OF ONCOGENE C-FOS AND HEAT SHOCK PROTEIN (HSP70) GENE IN BRAIN OF MIDDLE CEREBRAL ARTERY OBSTRUCTIVE RATS

Tao Lan

Abstract

By using molecular hybridization method,we studied c fos and HSP70 gene expression in brain of MCAo rats.The results showed that c fos and HSP70 gene could be indeuced by ischemia.The expression of these two genes were different in the time after ischemia in different parts of brain.c fos was mainly induced in hippocampus and cortex of brain,whereas HSP70 expressed predominantly in cortex and corpus striatum.These results suggested that the induction of c fos gene correlated with ischemia induced injury,and could be looked as an early reactive marker of brain injury.HSP70 was a protective protein,which was related to brain tolerance to ischemia.

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Key concepts: Hsp70, Heat shock protein, Ischemia, Striatum, Cortex (anatomy), Gene expression, Hippocampus, In situ hybridization