1999•Chinese Journal of DermatologyRequires access
Establishment of Hair Cycle Animal Model with C57BL6 Mice
Shuxia Yang, Shengqing Ma, Zhihong Zhong, Jian Qin, Zhixin Li
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Abstract
Objective
To established an animal model for studying the hair cycle.
Methods
Using C57BL6 mice as animal model, hair shafts of 25 mice were depilated by wax/resin mixture to induce the hair follicles from telogen to anagen. Skin color and histological changes were observed daily.
Results
After depilation, the skin color of those mice turned from pink (telogen) to black (anagen) in day 5～6 and turned from gray (catagen) to pink (telogen) in day 17～19. Histologically, anagen (substage IV) took place in day 5～6, changed to catagen in day 17～19, and entered telogen in day 20 after depilation.It showed that depilation by wax/resin mixture could induce C57BL6 mice from telogen to highly synchronized hair growth cycle. The changes of skin color were consistent with the histological changes of hair cycle.
Conclusion
C57BL6 mice could be used as an animal model for further studies on hair cycle.
Key words:
Hair Mice, inbred C57BL6