Comparison of two kinds of stimulus sounds in the ABR test for senescence accelerated mouse/prone8(SAMP8)

Objective To compare the similarities and differences between two kinds of stimulus sounds in the auditory brainstem response(ABR) test for senescence accelerated mouse/prone8(SAMP8),and to give advices for the ABR test of animal models of age-related hearing loss.Methods Click and 8kHz tone burst were used respectively in the ABR test for SAMP8 and senescence accelerated mouse/resistance 1(SAMR1).Recorded and compared the ABR test results in each group.Results (1)Compared with the control group′s,the tone burst ABR thresholds of experimental group,4 months and 10 months SAMP8 were significantly higher(P0.05 and P0.01);while the experimental group′s,the click ABR thresholds occurred only 10 months SAMP8 significantly higher(P0.05);(2)The binaural tone burst ABR thresholds of 4 months SAMP8 were significantly higher (P0.05).Conclusion The 4 months SAMP8 appear a significant decline in auditory function which shows presbyacousis performance.While the tone burst ABR can be sensitive to assess the early decline in auditory function of SAMP8.