The correlation of EBV in plasma and primary tumor volume of NPC

Objective:To investigate plasma EB virus copy number and positive rate of the primary disease and nasopharyngeal carcinoma tumor size correlation.Methods:collection from September 2008 to September 2009 in Cancer Center of Sun Yat-sen first diagnosed 722 cases of nasopharyngeal carcinoma patients,according to MRI imaging observation of nasopharyngeal cancer in accordance with the scope of China's 2008 staging of nasopharyngeal carcinoma criteria for T staging of primary lesions. At the same time in the plasma of patients before treatment for the quantitative determination of EB virus DNA to calculate the copy number and positive rate.Results:The patients with NPC plasma EBV-DNA copy number and positive rate and tumor size or clinical T stage were positively correlated,the difference was significant (P0.01).T staging of nasopharyngeal carcinoma is the later stages,patients with plasma EBV-DNA copy number higher.Conclusions:NPC patients before treatment,plasma EB virus DNA copy number and positive rate of nasopharyngeal primary tumor size was significantly related,may serve as the primary nasopharyngeal lesion size as a complementary molecular biological indicators ,the disease has significant value judgments,is worthy of clinical application.