Antimicrobial Agent Resistance of Escherichia coli Isolated from Clinic

OBJECTIVE To analyze the drug-resistance of Escherichia coli isolated from clinic in the past two years. METHODS The drug-resistance to 19 kinds of antimicrobial agents of 435 E. coli strains was detected by K-B method. 3-D test was performed to detect AmpC β-lactamase and Extended-spectrum β-lactamases(ESBLs). RESULTS It showed that the strains from cervical secretions, urine, throat swab and lochia specimens had the highest positive rate. Sensitivity test results showed that the resistance rate to ampicillin, aztreonam, sulfamethoxazole/trimethoprims and quinolones was high (49.23-84.10%), and resistance rate to the third, and fourth-generation cephalosporins was high too(31.35-46.80%). Strains that resistant to imipenem and meropenem were not detected out and they had a high sensitivity rate (93.38%), to cefoperazone/sulbactam. Detection rate of ESBLs and AmpC was 32.67% and 5.52%, respectively. Nineteen srtains produced both of them and 6 srtains produced AmpC only. CONCLUSIONS The detection rate and drug resistance are increasingly severe. Clinic and laboratory should make efforts to reduce hospital infection and dissemination of drug-resistant strains.