Investigation on Immunogenicity and Immunization Procedure of China-made Live Attenuated Measles-mumps-rubella Combined Vaccine

Objective To evaluate the safety,immunogenicity and immunization procedure of the measles-mumps-rubella combined vaccine(MMR) produced by Beijing Biological Product Institute.Methods Eight months old children were selected to be vaccinated with Beijing MMR vaccine.The local and systemic site effects were examined within 30 min after vaccination and within 24 h,48 h,5 d,7 d,9 d of vaccination respectively.The positive seroconversion rates and the geometric mean titer(GMT) of antibodies of measles,mumps and rubella were tested for 6 weeks after vaccination.Results The results show that among 91 children of 8 months were vaccinated with Beijing MMR vaccine,8 children had transient fever,2 children had signs of rashes and 2 child had mild local effects.The positive seroconversion rates of measles,mumps and rubella anti-HI were 98.61%,100.00% and 74.07% respectively.The GMTs were 45.25,248.71 and 4.29 respectively.Conclusion Beijing MMR vaccine had good safety and immunogenicity to 8 months old children.The 8 months old children was thought to be rational age for children in immunization procedure of Beijing MMR vaccine.