2013•Journal of Tissue Engineering and Reconstructive SurgeryRequires access

Transplantation of Human Umbilical-Cord Mesenchymal Stem Cells in Treatment of Cerebellar Atrophy

Zhifang Xu

Abstract

Objective To evaluate the clinical effectiveness of transplantation of human umbilical-cord mesenchymal stem cells(hUMSCs) in the treatment of cerebellar atrophy(CA).Methods The mesenchymal stem cells(MSCs) were separated from umbilical-cord of healthy newborn and were cultured to a large amount in vitro.Then hUMSCs were transplanted(cell amount: 1.0×108) into CA patients(57 cases) by intra-dural injection(2.5×107/5 mL) and intravenous injection(7.5×107/100 mL).Results All the patients were followed up for 6 months.The effective rate were 72.0% 3 months after transplantation and 79.0% 6 months after transplantation respectively.No complication were observed.Conclusion hUMSCs treating CA is safe and effective,but its long-term effectiveness should be further observed.

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Key concepts: Umbilical cord, Mesenchymal stem cell, Transplantation, Medicine, Surgery, Stem cell, Atrophy, Pathology