Effects of PTS on Focal Cerebral Ischemia and Cerebral Blood Flow in Rat

Objective To study the protective effects of PTS on focal cerebral ischemia in rats.Method Rats were randomly divided into 6 groups:the Sham,the Control,the PTS(25 mg,50 mg and 100 mg/kg),and the XST.The rat's mode of focal cerebral ischemia was made by middle cerebral artery occlusion(MCAO) with nylon suture;the effects of the drug were studied about neurological deficit,the water content of brain tissue,the activities of SOD,and MDA in brain tissue,the cerebral infracted zone,as well as undermicroscopic examination.Result PTS(50 mg and 100 mg/kg) could significantly reduce the scores for neurological deficits and brain edema,improve the activities of SOD,lower the content of MDA,reduce the cerebral infracted zone and alleviate the injury of cerebral ischemia.Conclusion PTS has obviously protective effects on the focal cerebral ischemia in rats,the increase of rCBF may be one of the protection mechanism.