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2011•Unpublished venueRequires access

Clinical study on reversal of multidrug resistance in relapsed or refractory acute leukemias by cyclosporine A and interferon

Shan Shun-lin

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Abstract

Objective:To explore the clinical implication of reversal of multidrug resistance(MDR)by cyclosporine A(CsA) and interferon-α(IFN-α).Methods: The expression of P-170 was assaied by means of immunocytochemistry,45 cases who were P-170 positive were randomly divided into groups: trial group(chemotherapy plus CSA and IFN-α)and control group(chemotherapy alone).Results: The incidence of P-170 expression(66.7%)was higher in relapsed of refractory acute leukemias,effective rates were 78.9% and 42.9% respression(P0.05).Conclusion: CsA and IFN-a were safe and effective for reversal of MDR in relapsed or retractory acute leukemia.

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What this paper is about

Objective:To explore the clinical implication of reversal of multidrug resistance(MDR)by cyclosporine A(CsA) and interferon-α(IFN-α).Methods: The expression of P-170 was assaied by means of immunocytochemistry,45 cases who were P-170 positive were randomly divided into groups: trial group(chemotherapy plus CSA and IFN-α)and control group(chemotherapy alone).Results: The incidence of P-170 expression(66.7%)was higher in relapsed of refractory acute leukemias,effective rates were 78.9% and 42.9% respression(P0.05).Conclusion: CsA and IFN-a were safe and effective for reversal of MDR in relapsed or retractory acute leukemia.

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Available abstract

Objective:To explore the clinical implication of reversal of multidrug resistance(MDR)by cyclosporine A(CsA) and interferon-α(IFN-α).Methods: The expression of P-170 was assaied by means of immunocytochemistry,45 cases who were P-170 positive were randomly divided into groups: trial group(chemotherapy plus CSA and IFN-α)and control group(chemotherapy alone).Results: The incidence of P-170 expression(66.7%)was higher in relapsed of refractory acute leukemias,effective rates were 78.9% and 42.9% respression(P0.05).Conclusion: CsA and IFN-a were safe and effective for reversal of MDR in relapsed or retractory acute leukemia.

Key concepts: Refractory (planetary science), Medicine, Multiple drug resistance, Chemotherapy, Acute leukemia, Incidence (geometry), Internal medicine, Interferon

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Clinical study on reversal of multidrug resistance in relapsed or refractory acute leukemias by cyclosporine A and interferon — Research Paper | ScholarLens