An experimental study of treatment of hemorrhagic shock using hypertonic sodium chloride solution in dogs

Objective To find out the optimal concentration, infusion rate and dosage of sodium chloride solution for resuscitation. Methods A total of 45 hemorrhagic shock dog models were established, resuscitated with sodium chloride solution with different concentration and dosage under different infusion rate and compared with the resuscitation results. Results The best concentration is 75 g/L, the best infusion rate 20 ml/min, and a volume equivalent to 15% of shed blood (5.71 mg/kg) the best dosage. Such method was effective because resuscitation for MAP could be elevated to 89% of the baseline and kept stable for more than 1 hour. Conclusions A volume of 75 g/L sodium chloride solution at infusion rate of 20 ml/min equivalent to 15% of shed blood can achieve the best resuscitation.