2008•Journal of Zhengzhou UniversityRequires access
Expression of neurofibromin and Ras-p21 protein in neurofibromas tissue from neurofibromatosis type 1 patients
Xiaomei Zhai
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Abstract
Aim:To investigate the differences in the expression of neurofibromin and Ras-p21 in neurofibromas tissue of neurofibromatosis type1(NF1) and solitary neurofibroma(SNF).Methods:The expression of neurofibromin and Ras-p21 protein in neurofibromas tissue from 19 cases of NF1 and 16 cases of SNF were detected using Western-blot.11 cases of normal nerve tissue were the control.Results: The expression of neurofibromin in neurofibromas tissue from NF1 group was significant lower than those from SNF group and the control group (P0.05), while the expression of Ras-p21 protein was higher than those from SNF group and the control group (P0.05). No difference in the expressions of neurofibromin and Ras-p21 between the SNF group and the control group were found.Conclusion:NF1 gene leading to the deletion of neurofibromin which resulted in the deletion of Ras-p21 may be involved into the NF1 pathogenesis.The detection of neurofibromin may be helpful for NF1 diagnosis and differentiation to SNF.