Preparation and characteristics of nimodipinepolylactic acid microspheres

OBJECTIVE To prepare nimodipine polylactic acid microspheres and study its characteristics.METHODS Using solvent evaporation extraction method to prepare the microspheres and analyzing some factors influencing the technology with orthogonal design.The surface morphology of the microspheres was scanned under electron microscope and the formulation of microspheres was confirmed by FTIR.The powder partical's characteristics such as mean diameter,drug loading rate and entrapment rate were evaluated comprehensively,and its dissolution characteristics in vitro were studied.RESULTS The microspheres were round and the surface was smooth,the average particle size was(61.7±0.46)μm,drug loading rate was(53.2±0.8)% and the entrapment rate was(86.2±0.6)%.The drug release in vitro profile could be described by Higuchi equation Q=17.708t1/2-0.975 8(r=0.995 4),t1/2=8.29 d.CONCLUSION This paper describes the optimized preparation conditions of sustained-release nimodipine polylactic acid microspheres.