Protective Effects of Sufentanil on Acute Myocardial Ischemia/reperfusion Injury in Rats

Objective To explore the protective effects of sufentanil precondition on myocardium ischemia/reperfusion(I/R) injury.Methods The myocardial idchemia and reperfusion injury model was established.The animals were randomly divided into 4 groups: sham operation group(sham,n=12);ischemia-reperfusion control group(I-R,n=12);ischemic preconditioning group(IPC,n=12)and sufentanil preconditioning group which was further divided into 3 subgroups according to the dose of sufentanil(SPC).In I-R group the hearts were subjected to 30 min ischemia followed by 90 min reperfusion(I/R).In IPC group the hearts were subjected to 3 episodes of 5 min ischemia in succession at 5 min interval for reperfusion before I/R.In SPC group the animals received 3 periods of 5 min remifentanil infusion at 0.25(SPCl,n=12),1(SPC2,n=12),5(SPC3,n=12)ug/kg at 5min interval before I/R.LVSP and ±dp/dtmax were recorded before and after I/R.Morphological change of the heart was observed by electron microscopy.Results ①In the ischemic/reperfused period,LVSP and ±dp/dt were significantly lower in the I-R group as compared with the Sham group(P0.01),which were higher in the IPC and SPC groups than those of I-R group(P0.05,P0.01).② Myocardial injury in group IPC and SPC was less severe than that in I-R group.Conclusion Sufentanil precondition has protective effects on acute myocardial infarction against I/R injury in rats.