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Research On the Asymmetric Hydrogenation of Acetophenone Catalyzed by Chiral Iridium (I) Systems

Chun-Liang Tang

Abstract

The chiral system generated insitu from chiral PNNP ligand and [Ir(COD)Cl] 2 was used in the asymmetric hydrogen-transfer hydrogenation of acetophenone to secondary alcohol, with 51% conversion and 66% enantiomeric excess under 45℃, when the mole ratio of acetophenone, iridium(I) complexes and potassium hydroxide is 5000:1:2; in some cases, up to 80% ee has been obtained. The effect of various reaction conditions on the activity and enantioselectivity had been studied.

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Key concepts: Acetophenone, Iridium, Enantiomeric excess, Chemistry, Catalysis, Potassium hydroxide, Enantiomer, Transfer hydrogenation