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2007•Chinese Journal of Otorhinolaryngology-skull Base SurgeryRequires access

Expression of cyclooxygenase-2 in nasopharyngeal carcinoma

Liu Gen-xun

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Abstract

Objective To explore the expression of cyclooxygenase-2(COX-2) in nasopharyngeal carcinoma(NPC) and its clinical significance.Methods The expression of COX-2 was detected by immunohistochemical method in specimens from 45 NPC patients and 20 cases of nasopharyngeal atypical hyperplasia.Results The positive rates of COX-2 in NPC patients and atypical hyperplasia patients were 71.1%(32/45),10.0%(2/20) respectively and the difference was statistically significant(P0.001).Conclusion The expression of COX-2 is enhanced in NPC tissue,which indicates COX-2 may play an important role in the pathogenesis and development of this tumor.

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What this paper is about

Objective To explore the expression of cyclooxygenase-2(COX-2) in nasopharyngeal carcinoma(NPC) and its clinical significance.Methods The expression of COX-2 was detected by immunohistochemical method in specimens from 45 NPC patients and 20 cases of nasopharyngeal atypical hyperplasia.Results The positive rates of COX-2 in NPC patients and atypical hyperplasia patients were 71.1%(32/45),10.0%(2/20) respectively and the difference was statistically significant(P0.001).Conclusion The expression of COX-2 is enhanced in NPC tissue,which indicates COX-2 may play an important role in the pathogenesis and development of this tumor.

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Available abstract

Objective To explore the expression of cyclooxygenase-2(COX-2) in nasopharyngeal carcinoma(NPC) and its clinical significance.Methods The expression of COX-2 was detected by immunohistochemical method in specimens from 45 NPC patients and 20 cases of nasopharyngeal atypical hyperplasia.Results The positive rates of COX-2 in NPC patients and atypical hyperplasia patients were 71.1%(32/45),10.0%(2/20) respectively and the difference was statistically significant(P0.001).Conclusion The expression of COX-2 is enhanced in NPC tissue,which indicates COX-2 may play an important role in the pathogenesis and development of this tumor.

Key concepts: Nasopharyngeal carcinoma, Immunohistochemistry, Cyclooxygenase, Pathogenesis, Atypical hyperplasia, Medicine, Hyperplasia, Pathology

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