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2014•Xinjiang Yike Daxue xuebaoRequires access

Real-time detection of cephalexin dissolution by FODT

Xi Li

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Abstract

Objective To detect drug release of cephalexin in vitro,and to establish a novel drug quality evaluation methodology by this instrument.Methods Detect and monitor cephalexin tablets dissolution by fiber optic drug dissolution tester(FODT).Results FODT could real-time detect dissolution rates of tablets in six different channels simultaneously.The within-day and between-day precision rates were 1.87% and 0.85%,respectively.And the recovery was 100.03%,while the relative standard deviation was 3.91%.The average dissolution of cephalexin tablets measured by FODT was(110.0±2.07)%,which showed no significant difference with the UV-method.Conclusion FODT could be applied to in vitro dissolution profile study,with reliable results,and it was of great importance in process optimization of pharmaceuticals.

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What this paper is about

Objective To detect drug release of cephalexin in vitro,and to establish a novel drug quality evaluation methodology by this instrument.Methods Detect and monitor cephalexin tablets dissolution by fiber optic drug dissolution tester(FODT).Results FODT could real-time detect dissolution rates of tablets in six different channels simultaneously.The within-day and between-day precision rates were 1.87% and 0.85%,respectively.And the recovery was 100.03%,while the relative standard deviation was 3.91%.The average dissolution of cephalexin tablets measured by FODT was(110.0±2.07)%,which showed no significant difference with the UV-method.Conclusion FODT could be applied to in vitro dissolution profile study,with reliable results,and it was of great importance in process optimization of pharmaceuticals.

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Available abstract

Objective To detect drug release of cephalexin in vitro,and to establish a novel drug quality evaluation methodology by this instrument.Methods Detect and monitor cephalexin tablets dissolution by fiber optic drug dissolution tester(FODT).Results FODT could real-time detect dissolution rates of tablets in six different channels simultaneously.The within-day and between-day precision rates were 1.87% and 0.85%,respectively.And the recovery was 100.03%,while the relative standard deviation was 3.91%.The average dissolution of cephalexin tablets measured by FODT was(110.0±2.07)%,which showed no significant difference with the UV-method.Conclusion FODT could be applied to in vitro dissolution profile study,with reliable results,and it was of great importance in process optimization of pharmaceuticals.

Key concepts: Dissolution, Dissolution testing, Chromatography, Relative standard deviation, Chemistry, Materials science, Detection limit, Physical chemistry

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