Correlation between pulse pressure and homocysteine,carotid artery intima-media thickness in senile patients with simple systolic hypertension

Objective: To study correlation between pulse pressure and homocysteine,carotid artery intima-media thickness in senile patients with simple systolic hypertension.Methods: Thirty-four senile patients with simple systolic hypertension(ISH) that were admitted to our hospital during March 2010 and March 2012 were selected as group A,30 cases of total period hypertension(SDH) patients were enrolled as group B,and 32 patients with isolated diastolic hypertension(IDH) as group C,another 30 healthy volunteers were selected as control group(group D).Pulse pressure(PP),serum homocysteine(HCY) and carotid artery intima-media thickness(IMT) were detected in all the subjects.Results: PP and serum HCY levels were(83.53± 8.07) mmHg,(27.54 ±4.16) mmol/L,respectively,both higher than those in group B,C and group D.The IMT of group A was(1.86 ±0.27) mm,significant different from that of group D(P0.05).For ISH patients,PP was positively correlated with serum HCY and IMT.Incidence of atheromatous plaque in carotid artery and ischemic stroke was 91.2%,61.8% in group A,significantly higher than that of group B,C and group D(P0.05).Conclusion: In elderly ISH patients,increased PP is correlated with elevated serum HCY levels and carotid artery IMT.Bedsides,PP and HCY are important impact factors in the progression of atherosclerosis.