The relationship between Galectin-3 expression in Meningioma and postoperative recurrence

Objective To study the relation between the expression of Galectin-3 and meningioma postoperative recurrence.Methods Sixty patients were collected in this study who applied Simpson level-Ⅰ resection,pathologically confirmed as meningioma,and they were followed up for at least 5 years.Then Galectin-3 protein was determined in pathological tissues by immunohistochemical method,and differences of Galectin-3 expression were observed in different categories.Results The expression of Galectin-3 protein in different pathological grade of meningiomas were significant differences(P0.05),the expression of Galectin-3 protein in malignant meningiomas and atypical meningiomas was significantly higher than that in benign meningiomas(P0.05).The expression of Galectin-3 protein in recurrent benign meningiomas group were significantly higher than that in the non recurrent benign meningiomas group(P0.05).Conclusion The expression of Galectin-3 protein in meningioma pathology and tumor recurrence has a certain relationship,which is higher with the increase of meningioma WHO pathological grade.The expression of Galectin-3 can be used as one of auxiliary indicators which can be used to determine whether the possibility of benign meningiomas' recurrence.