2007•Journal of Radiation Research and Radiation ProcessingRequires access
Effect of TGF-β1 on early remodeling of pulmonary injury following irradiation
XU Xin-ping
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Abstract
To investigate the role of TGF-β1 on the early lung remodeling after radiation pulmonary injury. The dose-effect of human lung fibroblast proliferation promoted by serum after radiated rat was observed by MTT col-orimetric methods. ELISA was used to observe the contents of TGF-β1 in serum as well as the expression of collagen IV and MMP-9 in HLF stimulated by serum after radiated rat. The level of TGF-β1 in rat serum increased from 2 to 4 weeks after irradiation. HLF proliferation was significantly promoted by the serum of irradiated rat at a dose of 10% in the medium. The serum of irradiated rat could not only promote HLF proliferation, but also increase the expres-sions of collagen IV and MMP-9 in HLF. TGF-β1 plays an important role in the proliferation of HLF and the expres-sions of collagen IV and MMP-9 in HLF, and is involved in the process of lung remodeling after radiation pulmonary injury.