ScholarLens Back to search
2009•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

The Effect of Food on Relative Bioavailability of Oral Lefucoxib

Mei Shi

Open publisher page 0 citations

Abstract

Aim To study the difference in pharmacokinetics and relative bioavailability of lefucoxib between Beagle dogs' intake of food and fasting before being given lefucoxib.Methods Celecoxib was used as the internal standard.Lefucoxib in Beagle dog plasma was determined by high-performance liquid chromatography with fluorescence detection.Results The lefucoxib' relative bioavailability was 3.98% and 29.7% respectively in case of intake of food and fasting.Conclusion Food can improve organisms' absorption of lefucoxib in vivo.

About this research paper

What this paper is about

Aim To study the difference in pharmacokinetics and relative bioavailability of lefucoxib between Beagle dogs' intake of food and fasting before being given lefucoxib.Methods Celecoxib was used as the internal standard.Lefucoxib in Beagle dog plasma was determined by high-performance liquid chromatography with fluorescence detection.Results The lefucoxib' relative bioavailability was 3.98% and 29.7% respectively in case of intake of food and fasting.Conclusion Food can improve organisms' absorption of lefucoxib in vivo.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Aim To study the difference in pharmacokinetics and relative bioavailability of lefucoxib between Beagle dogs' intake of food and fasting before being given lefucoxib.Methods Celecoxib was used as the internal standard.Lefucoxib in Beagle dog plasma was determined by high-performance liquid chromatography with fluorescence detection.Results The lefucoxib' relative bioavailability was 3.98% and 29.7% respectively in case of intake of food and fasting.Conclusion Food can improve organisms' absorption of lefucoxib in vivo.

Key concepts: Beagle, Bioavailability, Pharmacokinetics, Food intake, Absorption (acoustics), Chemistry, Plasma concentration, Food science

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Effect of Food on Relative Bioavailability of Oral Lefucoxib — Research Paper | ScholarLens