Ultrastructural Characteristics of Cortical Microvasculature after Global Cerebral Ischemia-reperfusion

Objective To investigate the dynamic changes in microvascular ultrastructure in the cortex after the acute cerebral ischemia-reperfusion.Methods 40 male rats were randomly divided into two groups(n=20 for sham operation group and cerebral ischemia-reperfusion group).Cerebral ischemia-reperfusion model was produced using suture middle cerebral artery occlusion.Rats were sacrificed and the brain samples were adopted 1,3,12,72 h after ischemia-reperfusion,methyl methacrylate composite brain microvascular casting.The production of brain microvascular specimens,scanning electron microscopy of normal rat cerebral cortex microvessels and cerebral cortex of acute brain injury morphological changes in microvascular.Results Compared with the sham-operated group,cerebral ischemia-reperfusion in the cortex after the signs of vascular damage,then,vascular casting was to bean shape or even had a completely broken tears candles stump-like vascular casting,finally,to further the formation of a vascular zone cortex.Conclusion The structural changes of brain microvascular in the cortex after acute cerebral ischemia-reperfusion is an important cause of cerebral microcirculation in rats.