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Determination of the dominant language hemisphere by functional MRI in patients with temporal lobe epilepsy.

Xiangyu Gao, Chengcheng Jiang, Lu Chen, Tsu‐Wang Shen

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Abstract

OBJECTIVE: To determine the dominant language hemisphere in patients with intractable temporal lobe epilepsy before surgical treatment by using functional MRI (fMRI). METHODS: Twelve patients underwent fMRI. Among them, 4 patients also underwent the Wada test. Anterior temporal lobectomy was performed on patients with epileptic focus on the non-dominant hemisphere, and selective amygdalo-hippocampectomy on patients with epileptic focus on the dominant hemisphere. RESULTS: Ten patients had left dominance, and 2 right dominance. The fMRI results were concordant with Wada test results in the 4 patients who accepted the Wada test. Seven patients underwent anterior temporal lobectomy, and 5 underwent selective amygdalo-hippocampectomy. There was no post-operative dysphasia. CONCLUSION: fMRI is an alternative method of noninvasive functional mapping for language dominance in patients with temporal lobe epilepsy.

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OBJECTIVE: To determine the dominant language hemisphere in patients with intractable temporal lobe epilepsy before surgical treatment by using functional MRI (fMRI). METHODS: Twelve patients underwent fMRI. Among them, 4 patients also underwent the Wada test. Anterior temporal lobectomy was performed on patients with epileptic focus on the non-dominant hemisphere, and selective amygdalo-hippocampectomy on patients with epileptic focus on the dominant hemisphere. RESULTS: Ten patients had left dominance, and 2 right dominance. The fMRI results were concordant with Wada test results in the 4 patients who accepted the Wada test. Seven patients underwent anterior temporal lobectomy, and 5 underwent selective amygdalo-hippocampectomy. There was no post-operative dysphasia. CONCLUSION: fMRI is an alternative method of noninvasive functional mapping for language dominance in patients with temporal lobe epilepsy.

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Available abstract

OBJECTIVE: To determine the dominant language hemisphere in patients with intractable temporal lobe epilepsy before surgical treatment by using functional MRI (fMRI). METHODS: Twelve patients underwent fMRI. Among them, 4 patients also underwent the Wada test. Anterior temporal lobectomy was performed on patients with epileptic focus on the non-dominant hemisphere, and selective amygdalo-hippocampectomy on patients with epileptic focus on the dominant hemisphere. RESULTS: Ten patients had left dominance, and 2 right dominance. The fMRI results were concordant with Wada test results in the 4 patients who accepted the Wada test. Seven patients underwent anterior temporal lobectomy, and 5 underwent selective amygdalo-hippocampectomy. There was no post-operative dysphasia. CONCLUSION: fMRI is an alternative method of noninvasive functional mapping for language dominance in patients with temporal lobe epilepsy.

Key concepts: Wada test, Temporal lobe, Epilepsy, Anterior temporal lobectomy, Lateralization of brain function, Medicine, Epilepsy surgery, Dominance (genetics)

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Determination of the dominant language hemisphere by functional MRI in patients with temporal lobe epilepsy. — Research Paper | ScholarLens