2010•PubMedRequires access

[Pharmacokinetics studies on tetramethylpyrazine by intravenous administration in rats].

Hainan Chen, Sha Li, Xing-Li Wang, Yuqiang Wang

Abstract

OBJECTIVE: To investigate the pharmacokinetics behaviour of tetramethylpyrazine (TMP) by intravenous administration in rats. METHODS: Methanol-0.05 mol/L acetate buffer solution (50:50,V/V) was used as mobile phase with a flow rate of 1.0 mL/min. The UV detection wavelength was 280 nm. RESULTS: The profile of TMP in blood fitted a two-compartment model. The half time of drug distribution and elimination was short. The mean residence time MRT 0-infinity was 141.61 min, and the AUC0-infinity was 7521.70 microg x min/ mL. CONCLUSION: After intravenous injection, the pharmacokinetics behaviour of TMP fit a two-compartment model in rats. Both the distribution and the elimination are fast.

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Key concepts: Tetramethylpyrazine, Pharmacokinetics, Distribution (mathematics), Pharmacology, Chemistry, Chromatography, Compartment (ship), Medicine