Optimization of Reprogramming Methods for Induced Pluripotent Stem Cells and Prospect on Their Space Medicine Potential Application

Induced pluripotent stem cells(iPSCs)with characteristics identical to those of embryonic stem cells(ESCs)directly in vitro reprogrammed from somatic cells through transfacting a few specific transcription factors have captured great attention in research of somatic cells.However,low-efficiency reprogramming and safety seriously hamper development of clinical application.Effects of space environment on differentiation activity of multiple potent stem cells is one of reasons for astronants′physiological changes.So iPSCs changes in space special conditons will provoke new insight for developmental biology and regeneration medicine.This review summarizes the researh progress of iPSCs,the method and application of improving reprogramming efficiency and safety,and the future in space medicine is prospected.