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2012•Zhongguo redai yixueRequires access

Effect of hyperoxia on the expression of surfactant protein C in newborn rats

Yang Yong-ling

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Abstract

Objectives To explore the effect of hyperoxia on expression of surfactant protein C(SP-C)in newborn rats.Methods The 72 newborn SD rats were randomly divided into air group and hyperoxia group.Each group has 36 rats.The rats in every group were randomly into the 3rd,7th,14th day subgroups respectively.The sub-groups of 3rd,7th and 14th were cut lung tissue in the corresponding of time,expression of SP-C protein was detected by immunohistochemistry.Results The expression of SP-C in hyperoxia group was stronger than air group in 3rd day,P0.05;The expression of SP-C showed no significant difference between hyperoxia group and air group in 7th day,(P0.05),Significant difference was noticed between hyperoxia group and air group in 14th day,(P0.01).Conclusion Hyperoxia exposure lead to a down regulation or functional impairment of the SP-C expression,this may be an important factor for hyperoxia lung injury.

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What this paper is about

Objectives To explore the effect of hyperoxia on expression of surfactant protein C(SP-C)in newborn rats.Methods The 72 newborn SD rats were randomly divided into air group and hyperoxia group.Each group has 36 rats.The rats in every group were randomly into the 3rd,7th,14th day subgroups respectively.The sub-groups of 3rd,7th and 14th were cut lung tissue in the corresponding of time,expression of SP-C protein was detected by immunohistochemistry.Results The expression of SP-C in hyperoxia group was stronger than air group in 3rd day,P0.05;The expression of SP-C showed no significant difference between hyperoxia group and air group in 7th day,(P0.05),Significant difference was noticed between hyperoxia group and air group in 14th day,(P0.01).Conclusion Hyperoxia exposure lead to a down regulation or functional impairment of the SP-C expression,this may be an important factor for hyperoxia lung injury.

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Available abstract

Objectives To explore the effect of hyperoxia on expression of surfactant protein C(SP-C)in newborn rats.Methods The 72 newborn SD rats were randomly divided into air group and hyperoxia group.Each group has 36 rats.The rats in every group were randomly into the 3rd,7th,14th day subgroups respectively.The sub-groups of 3rd,7th and 14th were cut lung tissue in the corresponding of time,expression of SP-C protein was detected by immunohistochemistry.Results The expression of SP-C in hyperoxia group was stronger than air group in 3rd day,P0.05;The expression of SP-C showed no significant difference between hyperoxia group and air group in 7th day,(P0.05),Significant difference was noticed between hyperoxia group and air group in 14th day,(P0.01).Conclusion Hyperoxia exposure lead to a down regulation or functional impairment of the SP-C expression,this may be an important factor for hyperoxia lung injury.

Key concepts: Hyperoxia, Surfactant protein C, Immunohistochemistry, Lung, Pulmonary surfactant, Protein expression, Internal medicine, Room air distribution

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