Comparison of the residual neuromuscular blockade caused by the different administration ways of cisatracurium

Objective To observe the residual neuromuscular blockade caused by different administration ways of cisatracurium(continuous infusion and intermittent bolus injection). Methods Eighty ASA Ⅰ orⅡ patients,aged from 18to 70,undergoing selective spinal surgery with general anesthesia,were equally randomized into four groups(n=20).Patients received cisatracurium by continuous infusion with 1.5μg·kg-1·min-1in group A1and 0.75μg·kg-1·min-1 in group A2, patients received intermittent bolus injection with 0.1 mg·kg-1·h-1 in group B1 and 0.05 mg·kg-1·h-1 in group B2.The cisatracurium consumption and TOFr recovered to 25%,50%,75%, 90%,extubation time,continuing look up 5stime,tidal volume and respiratory rate before and after anesthesia were recorded.Results Compared with group A2,time of TOFr recovery to 25%,50%in gourp A1were significantly increased(P0.05).Compared with group B1,time of TOFr recovery to 25%in group A1was significantly increased(P0.05).Compared with group B2,time of TOFr recovery to 50%,75%in group A2were significantly increased(P0.05);time of TOFr recovery to 50%,75%,90%in group B1were significantly increased(P0.05).Compared with group A2,time of muscle strength recovery to Ⅳ-Ⅴ and continuing look up 5swere significantly increased(P 0.05).Conclusion Cisatracurium continuous infusion and intermittent bolus injection have no influence on the residual effect of muscle relaxant,but continuous infusion may effect on the time of muscle relaxant.