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2008•Chinese Journal of Public HealthRequires access

Effect of chronic lead exposure on expression of PKC-γ in mice hippocampus

Liguang Sun

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Abstract

Objective To observe the effect of chronic lead contamination on protein expression of PKC-γ in the hippocampus of mice.Methods Chronic acetic lead contamination was applied to mice(2.4,4.8,9.6 mmol/L),and young mice were killed at 14,21,35,48 d respectively.Western blotting was used to observe the protein expression levels of PKC-γ in hippocampus of mice.Results Compared with the control group,PKC-γ protein expression in the hippocampus of mice with chronic lead exposure was significantly down trended(P0.05).Conclusion Chronic lead exposure can disturb the normal expression of PKC-γ protein in mice.

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What this paper is about

Objective To observe the effect of chronic lead contamination on protein expression of PKC-γ in the hippocampus of mice.Methods Chronic acetic lead contamination was applied to mice(2.4,4.8,9.6 mmol/L),and young mice were killed at 14,21,35,48 d respectively.Western blotting was used to observe the protein expression levels of PKC-γ in hippocampus of mice.Results Compared with the control group,PKC-γ protein expression in the hippocampus of mice with chronic lead exposure was significantly down trended(P0.05).Conclusion Chronic lead exposure can disturb the normal expression of PKC-γ protein in mice.

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Available abstract

Objective To observe the effect of chronic lead contamination on protein expression of PKC-γ in the hippocampus of mice.Methods Chronic acetic lead contamination was applied to mice(2.4,4.8,9.6 mmol/L),and young mice were killed at 14,21,35,48 d respectively.Western blotting was used to observe the protein expression levels of PKC-γ in hippocampus of mice.Results Compared with the control group,PKC-γ protein expression in the hippocampus of mice with chronic lead exposure was significantly down trended(P0.05).Conclusion Chronic lead exposure can disturb the normal expression of PKC-γ protein in mice.

Key concepts: Hippocampus, Protein kinase C, Protein expression, Blot, Internal medicine, Endocrinology, Lead exposure, Chemistry

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