2013•The Chinese Journal of Clinical PharmacologyRequires access
Pharmacokinetics of paracetamol within paracetamol and tramadol hydrochloride dispersible tablets in healthy volunteers
Sun Bi
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Abstract
Objective To investigate the pharmacokinetics of paracetamol within paracetamol and tramadol hydrochloride dispersible tablets in healthy volunteers. Methods The 10 healthy volunteers were divided into receiving a single dose of 1 or 2 pieces paracetamol and tramadol hydrochloride dispersible tablets( each piece contains 37. 5 mg tramadol hydrochloride and 325 mg paracetamol) respectively. Results The main pharmaeokinetic parameters of paracetamol after single oral doses( 1 or 2 pieces) were as follows: c max were( 3920. 22 ± 1258. 58),( 7227. 45 ± 1838. 02) ng·mL1,t max were( 1. 10 ± 0. 75) and( 1. 20 ± 0. 68) h,t 1 /2 were( 3. 62 ± 1. 10) and( 5. 52 ± 3. 46) h,AUC 0t were( 17. 12 ± 4. 60) and( 39. 24 ± 8. 29) μg·h·mL1. Conclusion The value of c max and AUC will increase following the increase of doses. The pharmacokinetic characteristic of paracetamol in Chinese healthy volunteers are fitted with linear kinetic model.