The effects on the perinatal newborn in intrahepatic cholestasis of pregnancy

Objective: To study the effects on perinatal newborn with ICP. Methods: From January 2000 to December 2002. 72 cases of pregnant women with ICP, who delivered by cesarean section were collected. To observe the amniotic fluid meconium contamination, fetal distress, premature delivery, asphyxia of newborn, neonatal aspiration pneumonia. 70 cases of normal pregnancy of similar age, who delivered by cesarean section, were used as control group. The ultrastructures of the placental tissue were studied with electronic microscope. Results:The percentage of amniotic fluid meconium contamination, fetal distress, premature delivery, asphyxia of newborn, neonatal aspiration pneumonia were 30.56%,23.61%, 16.67%, 5.56%, 16.67% respectively, which were significantly higher than that in control group (P0.05~ 0.01). There was obvious pathologial change in the placental tissue ultrastructure in ICP group. Conclusion: ICP can induce premature delivery, fetal distress, asphyxia of newborn, amniotic fluid meconium contamination, neonatal aspiration pneumonia. The pathological change of the placental tissue ultrastructure closely is related to the prognosis of perinatal newborn.