Combination of sufentanil and dezocine in patient-controlled analgesia after gynaecologic surgery

Objective To observe the security and feasibility of combination of dezocine and sufentanil in patient-controlled analgesia after gynaecologic surgery.Methods One-hundred and twenty patients aged between 18 and 65 years old with an ASA physical status I or II undergoing gynaecologic surgery were randomly divided into three groups: sufentanil 150μg in S group;Dezocine 10mg and sufentanil 100μg in SD group;Dezocine 10mg in D group.Each drug was diluted to 100ml and infused by a pump at a rate of 2ml/h with a patient-controlled bolus of 0.5ml after a loading dose of fentanil 1μg/kg.The visual analog scale,score of sedation,drug consumption and incidence of side effects were recorded at 4,8,24 and 48 h after operation by the investigators.Results The VAS values of group S and group SD within 48 hours were significantly lower than those of group D;Between 4 and 24 hours the scores of sedation of group S was significantly higher than those of group SD and group D;The incidence of nausea,vomiting,pruritus and respiratory depression were not significantly different between three groups.Conclusion Combinations of dezocine and sufentanil in PCA can attain better analgesia compared to dezocine and decrease the incidence of drowsiness compared to sufentanil.This may provide a novel combination strategy of opioid agonist and agonist-antagonist for postoperative pain management after gynaecologic surgery.