Late Progresses in Research of ECM_1,MMP-9 and Gastric Cancer

Extracellular matrix protein-1(ECM1) is a kind of secreted glycoprotein,which can promote endothelial cells proliferation and angiogenesis.ECM1 expression is significantly elevated in gastric cancer tissues and other malignant epithelial tumors,which gives rise to its potential correlation with tumor infiltration and metastasis.Matrix metalloproteinase-9(MMP-9) can degrade the basement membrane and the extracellular matrix,promote vascularization and enhance the invasiveness and metastasis of gastric cancer cells.Thus,to discuss the roles of ECM1 and MMP-9 in the carcinogenesis and development of gastric cancer will help further realize the interaction of cancer cells and their surrounding microenvironment,and provide theoretical basis for early diagnosis and treatment of gastric cancer.