Effect of L-NNA on Concentrations of Plasma Endothelin of Patients with Cerebral Infarction

Objective To investigate the treatment mechanism of L-NNA to the cerebral infarction.Methods 10 patients of acute cerebral infarction(treatment group) were treated with L-NNA,while the control group of acute cerebral infarction(10 cases) was treated with low molecular weight dextran and citicoline.The degree of functional defect of nervous system and symptom improvement were observed,in the meantime,the concentration changes of plasma endothelin(ET) in blood were measured as well.Then,the comparison between two groups was carried out.Results The patients' function of nervous system in treatment group was improved more significantly than that of control group.Total effective rate in treatment group was 90.0% and total responsive rate in treatment group was 60.0%,superior to that of control group(80.0% and 40.0% respectively,P0.05).However,the concentration of ET in treatment group was much more decreased than control group(P0.05).Conclusion The therapeutic mechanism of L-NNA on cerebral infarction probably could be explained through its elimination and inhibition for mation and release of ET.