Effects of Different Anesthetic Methods on Patients′ Stress Reaction in Intraoperative Wake-up Test

Objective To compare the effects of different anesthetic methods on patients′ stress reaction in intraoperative wake-up test.Methods Sixty patients undergoing scoliosis surgery were scheduled into two groups randomly:intravenous anesthesia with propofol+remifentanil(Group A,n=30),anesthesia with sevoflurance+remifentanil(Group B,n=30).The injection with atracurium was stopped 30 min before patients′ wake-up in both groups,then the injection with propofol and remifentanil was stopped 10 min before patients′ wake-up in Group A,while the injection with sevoflurance and remifentanil was stopped in Group B.Heart rate(HR),mean arterial pressure(MAP),blood glucose and plasma cortisol concentration were recorded at the following time points:T1:the time of stopping propofol,remifentanil and sevoflurance;T2:wake-up time;T3:15 min after deeper anesthesia;and the wake-up time and analepsia quality were observed.Results There was no significant difference between two groups in the wake-up time[(11.2±1.3)min vs(10.7±2.1)min,P0.05].The analepsia quality in Group A was superior to that in Group B(P0.05).HR,MAP,blood glucose and plasma cortisol concentration at T2 were all higher than those at T1 in both groups(P0.05).But HR,MAP,blood glucose and plasma cortisol concentration of Group A at T1 or T2 or T3 were all lower than those of Group B(P0.05).Conclusion In the intraoperative wake-up test,the degree of stress reaction of patients receiving intravenous anesthesia with propofol and remifentanil is lower than that of patients receiving remifentanil and sevoflurance anesthesia during scoliosis surgery.