Preventive and Therapeutic Effect of Tanshinone IIA on Postoperative Intestinal Adhesions of Rats

Objective To investigate the preventive and therapeutic effect of tanshinone IIA on postoperative intestinal adhesions of rats,and to measure the content of IL-1β,tPA and PAI in serum.Methods The animal models of intestinal adhesions were established.Seventy rats were randomly divided to sham-operated group,model control group,high-,medium-,low-dose group,tanshinone IIA-free group,and positive drug group,and 10 rats in each group.Rats in the positive drug group were injected into the abdominal cavity by dexamethasone,sham-operated group.Rats in the model control group were injected by normal saline,and rats in the tanshinone IIA-free group were injected with equal volume of tanshinone IIA-free solution.The expression of IL-1β,tPA,and PAI in serum were measured at-1,1,3,5,and 7 d.Results The expression of IL-1β in rats of high-,medium-,low-dose group and positive drug group were significantly lower compared with that of the sham-operated group,tanshinone IIA-free group,model control group and tanshinone IIAfree group(P 0.05).The expression of tPA were significantly higher than that of the sham-operated group,tanshinone IIA-free group,and model control group(P 0.05).The expression of PAI were significantly lower than that of the model control group and tanshinone IIA-free group(P 0.05),but there was no significant difference compared with sham-operated group.Conclusion Tanshinone IIA has preventive and therapeutic effect on postoperative intestinal adhesions and cecum injuries,its mechanism may be related to the decreases of IL-1β and PAI concentrations in serum,and the increases of tPA in serum.