Serum Procalcitonin and C Reactive Protein in Diagnosis of Neonatal Sepsis Patients

Objective:To evaluate the clinical significance of the detection of serum procalcitonin(PCT)and C reactive protein(CRP) in the diagnosis of neonatal sepsis.Method: PCT was determined by chemiluminescence immunoassay and CRP was measured by nephelometry.Result: The serum level of PCT and CRP in the neonatal sepsis group was(78.85±19.16)ng/mL and(53.17±35.68)mg/L respectively,which were much higher than those in the control group(0.35±0.13)ng/mL and(5.87±3.77)mg/L respectively(P 0.01).PCT and CRP had higher specificity,positive predictive value,accuracy and youden index.The levels of PCT and CRP were positively correlated to the severity of the illness.Conclusion: Concurrent determination of serum PCT and CRP could provide more accurate diagnostic evidence neonatal sepsis patients.