Changes of Hippocampal Nuclear Factor КB Expression in Rats with Epilepsy Kindled by Pentylenetetrazol

Objective To investigate the changes of hippocampal nuclear factor-kappaB(NF-KB)expression in rats with pentylenetetrazol(PTZ)-kindked epilepsy to find its pathogenesis.Methods Status epilepticus(SE)was induced by PTZ intraperitoneal injection to observe rat ethological changes,and immunohistochemistry and reverse transcription-polymerase chain reaction(RT-PCR)were used to determine hippocampal NC-KB expression of SE rats and control group at hours 1,6,24,72,respectively.Results In SE group,the hippocampal NF-KB expression began to increase after 6 hours,reaching the highest at hour 24(P0.05),and began to decrease at hour 72,but higher than normal control group.Conclusion NF-KB nuclear translocation,namely hippocampal neuron activation,is the major mechanism of the formation of PTZ-kindled epileptic rats,involving in epilepsy.