The Role of Nuclear Receptor Coregulation in Regulation of Gene Expression

Nuclear receptors are ligand inducible transcription factors.Nuclear receptor coregulators are coactivators,corepressors or cointegrators that are required by nuclear receptors for efficient transcriptional regulation.However,these proteins do not interact directly with DNA.Liganded receptors will recruit multiple coregulator proteins which may have specific functions during trascriptional initiation.eg.members of the SRC family are group of structurally and functionally related transcriptional coactivators,which can contact and activate basal transcription factors.CBP/P300 is proposed to integrate diverse afferent signals to promoters and have intrinsic histone acetyltransferase activity which is believed to disrupt the nucleosomal structure at these promoters.SMRT and NCoR are corepressors that act to silence gene transcription through interactions with DNA bound proteins.Transcriptional control is a multistep finely regulated process.It is anticipated that further study of nuclear receptor coregulators and their complexes will yield significant insights into the basis of the complexity of regulation of gene transcription.